4V5O

CRYSTAL STRUCTURE OF THE EUKARYOTIC 40S RIBOSOMAL SUBUNIT IN COMPLEX WITH INITIATION FACTOR 1.

これはPDB形式変換不可エントリーです。

4V5O の概要

• エントリーDOI: 10.2210/pdb4v5o/pdb
• 分子名称: RIBOSOMAL PROTEIN S28E CONTAINING PROTEIN, 18S RRNA, RPS0E, ... (38 entities in total)
• 機能のキーワード: ribosome, translation
• 由来する生物種: TETRAHYMENA THERMOPHILA; 詳細
• 細胞内の位置: Cytoplasm : 4V5O
• タンパク質・核酸の鎖数: 70
• 化学式量合計: 2424398.83

構造登録者

Rabl, J.,Leibundgut, M.,Ataide, S.F.,Haag, A.,Ban, N. (登録日: 2010-11-26, 公開日: 2014-07-09, 最終更新日: 2024-11-06)

主引用文献

Rabl, J.,Leibundgut, M.,Ataide, S.F.,Haag, A.,Ban, N.
Crystal Structure of the Eukaryotic 40S Ribosomal Subunit in Complex with Initiation Factor 1.
Science, 331:730-, 2011

PubMed Abstract: Eukaryotic ribosomes are substantially larger and more complex than their bacterial counterparts. Although their core function is conserved, bacterial and eukaryotic protein synthesis differ considerably at the level of initiation. The eukaryotic small ribosomal subunit (40S) plays a central role in this process; it binds initiation factors that facilitate scanning of messenger RNAs and initiation of protein synthesis. We have determined the crystal structure of the Tetrahymena thermophila 40S ribosomal subunit in complex with eukaryotic initiation factor 1 (eIF1) at a resolution of 3.9 angstroms. The structure reveals the fold of the entire 18S ribosomal RNA and of all ribosomal proteins of the 40S subunit, and defines the interactions with eIF1. It provides insights into the eukaryotic-specific aspects of protein synthesis, including the function of eIF1 as well as signaling and regulation mediated by the ribosomal proteins RACK1 and rpS6e.

PubMed: 21205638
DOI: 10.1126/SCIENCE.1198308

実験手法

X-RAY DIFFRACTION (3.93 Å)