4V1D

Ternary complex among two human derived single chain antibody fragments and Cn2 toxin from scorpion Centruroides noxius.

4V1D の概要

• エントリーDOI: 10.2210/pdb4v1d/pdb
• 分子名称: SINGLE CHAIN ANTIBODY FRAGMENT LR, HEAVY CHAIN, SINGLE CHAIN ANTIBODY FRAGMENT LR, LIGHT CHAIN, BETA-MAMMAL TOXIN CN2, ... (6 entities in total)
• 機能のキーワード: toxin-immune system complex, human scfv, scorpion venom neutralization, directed evolution, cn2 toxin., toxin/immune system
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Secreted: 4V1D
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 64315.96

構造登録者

Riano-Umbarila, L.,Serrano-Posada, H.,Rojas-Trejo, S.,Rudino-Pinera, E.,Becerril, B. (登録日: 2014-09-25, 公開日: 2015-10-07, 最終更新日: 2024-01-10)

• 主引用文献: Riano-Umbarila, L.,Ledezma-Candanoza, L.M.,Serrano-Posada, H.,Fernandez-Taboada, G.,Olamendi-Portugal, T.,Rojas-Trejo, S.,Gomez-Ramirez, I.V.,Rudino-Pinera, E.,Possani, L.D.,Becerril, B.; Optimal Neutralization of Centruroides Noxius Venom is Understood Through a Structural Complex between Two Antibody Fragments and the Cn2 Toxin.; J.Biol.Chem., 291:1619-, 2016; PubMed: 26589800; DOI: 10.1074/JBC.M115.685297

実験手法

X-RAY DIFFRACTION (3.1 Å)