4V10

Skelemin Association with alpha2b,beta3 Integrin: A Structural Model

4V10 の概要

• エントリーDOI: 10.2210/pdb4v10/pdb
• NMR情報: BMRB: 25242
• 分子名称: MYOMESIN-1 (1 entity in total)
• 機能のキーワード: structural protein, integrin
• 由来する生物種: MUS MUSCULUS (HOUSE MOUSE)
• 細胞内の位置: Cytoplasm, myofibril, sarcomere, M line : Q62234
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27092.94

構造登録者

Gorbatyuk, V.,Deshmukh, L.,Nguyen, K.,Vinogradova, O. (登録日: 2014-09-19, 公開日: 2014-10-08, 最終更新日: 2024-06-19)

主引用文献

Gorbatyuk, V.,Nguyen, K.,Podolnikova, N.P.,Deshmukh, L.,Lin, X.,Ugarova, T.P.,Vinogradova, O.
Skelemin Association with Alphaiibbeta3 Integrin: A Structural Model.
Biochemistry, 53:6766-6775, 2014

PubMed Abstract: Over the last two decades, our knowledge concerning intracellular events that regulate integrin's affinity to their soluble ligands has significantly improved. However, the mechanism of adhesion-induced integrin clustering and development of focal complexes, which could further mature to form focal adhesions, still remains under-investigated. Here we present a structural model of tandem IgC2 domains of skelemin in complex with the cytoplasmic tails of integrin αIIbβ3. The model of tertiary assembly is generated based upon NMR data and illuminates a potential link between the essential cell adhesion receptors and myosin filaments. This connection may serve as a basis for generating the mechanical forces necessary for cell migration and remodeling.

PubMed: 25224262
DOI: 10.1021/BI500680S

実験手法

SOLUTION NMR