4V0G

JAK3 in complex with a covalent EGFR inhibitor

4V0G の概要

• エントリーDOI: 10.2210/pdb4v0g/pdb
• 分子名称: TYROSINE-PROTEIN KINASE JAK3, N-[3-(2-{3-amino-6-[1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl]pyrazin-2-yl}-1H-benzimidazol-1-yl)phenyl]propanamide, ... (4 entities in total)
• 機能のキーワード: transferase, egfr mutant, t790m
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Endomembrane system ; Peripheral membrane protein : P52333 P52333
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65714.96

構造登録者

Debreczeni, J.E.,Hennessy, E.J.,Chuaquini, C.,Ashton, S.,Coclough, N.,Cross, D.A.E.,Eberlein, C.,Gingipalli, L.,Klinowska, T.C.M.,Orme, J.P.,Sha, L.,Wu, X. (登録日: 2014-09-16, 公開日: 2016-01-13, 最終更新日: 2024-11-06)

• 主引用文献: Hennessy, E.J.,Chuaquini, C.,Ashton, S.,Coclough, N.,Cross, D.A.E.,Debreczeni, J.E.,Eberlein, C.,Gingipalli, L.,Klinowska, T.C.M.,Orme, J.P.,Sha, L.,Wu, X.; Utilisation of Structure Based Design to Identify Novel, Irreversible Inhibitors of the Epidermal Growth Factor Receptor (Egfr) Harboring the Gatekeeper T790M Mutation; To be Published,

実験手法

X-RAY DIFFRACTION (3 Å)