4UZH

SAR156497 an exquisitely selective inhibitor of Aurora kinases

Summary for 4UZH

• Entry DOI: 10.2210/pdb4uzh/pdb
• Related: 4UZD
• Descriptor: AURORA 2 KINASE DOMAIN, (4S)-4-(2-fluorophenyl)-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b][1,7]naphthyridin-5-one (3 entities in total)
• Functional Keywords: transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: O14965
• Total number of polymer chains: 1
• Total formula weight: 33626.46

Authors

Pouzieux, S.,Maignan, S.,Crenne, J.Y. (deposition date: 2014-09-05, release date: 2014-11-19, Last modification date: 2015-01-21)

• Primary citation: Carry, J.C.,Clerc, F.F.,Minoux, H.,Schio, L.,Mauger, J.,Nair, A.,Parmantier, E.,Le Moigne, R.,Delorme, C.,Nicolas, J.P.,Krick, A.,Abecassis, P.Y.,Crocq-Stuerga, V.,Pouzieux, S.,Delarbre, L.,Maignan, S.,Bertrand, T.,Bjergarde, K.,Ma, N.,Lachaud, S.,Guizani, H.,Lebel, R.,Doerflinger, G.,Monget, S.,Perron, S.,Gasse, F.,Angouillant-Boniface, O.,Filoche-Romme, B.J.,Murer, M.,Gontier, S.,Prevost, C.,Monteiro, M.L.,Combeau, C.; Sar156497 an Exquisitely Selective Inhibitor of Aurora Kinases.; J.Med.Chem., 58:362-, 2015; PubMed: 25369539; DOI: 10.1021/JM501326K

Experimental method

X-RAY DIFFRACTION (2 Å)