4UZH
SAR156497 an exquisitely selective inhibitor of Aurora kinases
Summary for 4UZH
Entry DOI | 10.2210/pdb4uzh/pdb |
Related | 4UZD |
Descriptor | AURORA 2 KINASE DOMAIN, (4S)-4-(2-fluorophenyl)-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b][1,7]naphthyridin-5-one (3 entities in total) |
Functional Keywords | transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: O14965 |
Total number of polymer chains | 1 |
Total formula weight | 33626.46 |
Authors | Pouzieux, S.,Maignan, S.,Crenne, J.Y. (deposition date: 2014-09-05, release date: 2014-11-19, Last modification date: 2024-05-08) |
Primary citation | Carry, J.C.,Clerc, F.F.,Minoux, H.,Schio, L.,Mauger, J.,Nair, A.,Parmantier, E.,Le Moigne, R.,Delorme, C.,Nicolas, J.P.,Krick, A.,Abecassis, P.Y.,Crocq-Stuerga, V.,Pouzieux, S.,Delarbre, L.,Maignan, S.,Bertrand, T.,Bjergarde, K.,Ma, N.,Lachaud, S.,Guizani, H.,Lebel, R.,Doerflinger, G.,Monget, S.,Perron, S.,Gasse, F.,Angouillant-Boniface, O.,Filoche-Romme, B.J.,Murer, M.,Gontier, S.,Prevost, C.,Monteiro, M.L.,Combeau, C. Sar156497 an Exquisitely Selective Inhibitor of Aurora Kinases. J.Med.Chem., 58:362-, 2015 Cited by PubMed: 25369539DOI: 10.1021/JM501326K PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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