4UYN

SAR156497 an exquisitely selective inhibitor of Aurora kinases

Summary for 4UYN

• Entry DOI: 10.2210/pdb4uyn/pdb
• Descriptor: AURORA KINASE A, ethyl (9S)-9-[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]-8-hydroxy-5,6,7,9-tetrahydro-2H-pyrrolo[3,4-b]quinoline-3-carboxylate (3 entities in total)
• Functional Keywords: transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 33816.71

Authors

Carry, J.C.,Clerc, F.,Minoux, H.,Schio, L.,Mauger, J.,Nair, A.,Parmantier, E.,Lemoigne, R.,Delorme, C.,Nicolas, J.P.,Krick, A.,Abecassis, P.Y.,Crocq-Stuerga, V.,Pouzieux, S.,Delarbre, L.,Maignan, S.,Bertrand, T.,Bjergarde, K.,Ma, N.,Lachaud, S.,Guizani, H.,Lebel, R.,Doerflinger, G.,Monget, S.,Perron, S.,Gasse, F.,Angouillant-Boniface, O.,Filoche-Romme, B.,Murer, M.,Gontier, S.,Prevost, C.,Monteiro, M.L.,Combeau, C. (deposition date: 2014-09-02, release date: 2014-11-19, Last modification date: 2019-10-30)

• Primary citation: Carry, J.,Clerc, F.,Minoux, H.,Schio, L.,Mauger, J.,Nair, A.,Parmantier, E.,Le Moigne, R.,Delorme, C.,Nicolas, J.,Krick, A.,Abecassis, P.,Crocq-Stuerga, V.,Pouzieux, S.,Delarbre, L.,Maignan, S.,Bertrand, T.,Bjergarde, K.,Ma, N.,Lachaud, S.,Guizani, H.,Lebel, R.,Doerflinger, G.,Monget, S.,Perron, S.,Gasse, F.,Angouillant-Boniface, O.,Filoche-Romme, B.,Murer, M.,Gontier, S.,Prevost, C.,Monteiro, M.,Combeau, C.; Sar156497, an Exquisitely Selective Inhibitor of Aurora Kinases.; J.Med.Chem., 58:362-, 2015; PubMed: 25369539; DOI: 10.1021/JM501326K

Experimental method

X-RAY DIFFRACTION (1.9 Å)