4UYM
Crystal structure of sterol 14-alpha demethylase (CYP51B) from a pathogenic filamentous fungus Aspergillus fumigatus in complex with voriconazole
Summary for 4UYM
Entry DOI | 10.2210/pdb4uym/pdb |
Related | 4UYL |
Descriptor | 14-ALPHA STEROL DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, Voriconazole, ... (4 entities in total) |
Functional Keywords | cytochrome p450, heme, oxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum membrane |
Biological source | ASPERGILLUS FUMIGATUS |
Total number of polymer chains | 2 |
Total formula weight | 108431.22 |
Authors | Hargrove, T.Y.,Wawrzak, Z.,Lepesheva, G.I. (deposition date: 2014-09-02, release date: 2015-08-19, Last modification date: 2024-01-10) |
Primary citation | Hargrove, T.Y.,Warwzak, Z.,Lamb, D.C.,Guengerich, F.P.,Lepesheva, G.I. Structure-Functional Characterization of Cytochrome P450 Sterol Alpha-Demethylase (Cyp51B) from Aspergillus Fumigatus and Molecular Basis for the Development of Antifungal Drugs J.Biol.Chem., 290:23916-, 2015 Cited by PubMed: 26269599DOI: 10.1074/JBC.M115.677310 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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