4UYL

Crystal structure of sterol 14-alpha demethylase (CYP51B) from a pathogenic filamentous fungus Aspergillus fumigatus in complex with VNI

4UYL の概要

• エントリーDOI: 10.2210/pdb4uyl/pdb
• 関連するPDBエントリー: 4UYM
• 分子名称: 14-ALPHA STEROL DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, N-[(1R)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide, ... (4 entities in total)
• 機能のキーワード: cytochrome p450, oxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum membrane, oxidoreductase-oxidoreductase inhibitor complex
• 由来する生物種: ASPERGILLUS FUMIGATUS
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 108741.33

構造登録者

Hargrove, T.Y.,Wawrzak, Z.,Lepesheva, G.I. (登録日: 2014-09-01, 公開日: 2015-08-19, 最終更新日: 2024-01-10)

• 主引用文献: Hargrove, T.Y.,Warwzak, Z.,Lamb, D.C.,Guengerich, F.P.,Lepesheva, G.I.; Structure-Functional Characterization of Cytochrome P450 Sterol Alpha-Demethylase (Cyp51B) from Aspergillus Fumigatus and Molecular Basis for the Development of Antifungal Drugs; J.Biol.Chem., 290:23916-, 2015; PubMed: 26269599; DOI: 10.1074/JBC.M115.677310

実験手法

X-RAY DIFFRACTION (2.81 Å)