4UXN

LSD1(KDM1A)-CoREST in complex with Z-Pro derivative of MC2580

Summary for 4UXN

• Entry DOI: 10.2210/pdb4uxn/pdb
• Descriptor: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
• Functional Keywords: oxidoreductase, covalent inhibitor, tranylcypromine
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 2
• Total formula weight: 147279.40

Authors

Rodriguez, V.,Valente, S.,Stazi, G.,Lucidi, A.,Mercurio, C.,Vianello, P.,Ciossani, G.,Mattevi, A.,Botrugno, O.A.,Dessanti, P.,Minucci, S.,Varasi, M.,Mai, A. (deposition date: 2014-08-27, release date: 2015-02-25, Last modification date: 2024-01-10)

• Primary citation: Rodriguez, V.,Valente, S.,Rovida, S.,Rotili, D.,Stazi, G.,Lucidi, A.,Ciossani, G.,Mattevi, A.,Botrugno, O.A.,Dessanti, P.,Mercurio, C.,Vianello, P.,Minucci, S.,Varasi, M.,Mai, A.; Pyrrole- and Indole-Containing Tranylcypromine Derivatives as Novel Lysine-Specific Demethylase 1 Inhibitors Active on Cancer Cells; Chemmedchem, 6:665-670, 2015; DOI: 10.1039/C4MD00507D

Experimental method

X-RAY DIFFRACTION (2.85 Å)