4UWO

Native di-zinc VIM-26. Leu224 in VIM-26 from Klebsiella pneumoniae has implications for drug binding.

Summary for 4UWO

• Entry DOI: 10.2210/pdb4uwo/pdb
• Related: 4UWP 4UWR 4UWS
• Descriptor: METALLO-BETA-LACTAMASE VIM-26, SODIUM ION, ZINC ION, ... (5 entities in total)
• Functional Keywords: hydrolase, antibiotic resistance, klebsiella pneumoniae, drug binding site
• Biological source: KLEBSIELLA PNEUMONIAE
• Total number of polymer chains: 1
• Total formula weight: 28320.29

Authors

Leiros, H.-K.S.,Edvardsen, K.S.W.,Bjerga, G.E.K.,Samuelsen, O. (deposition date: 2014-08-14, release date: 2015-02-04, Last modification date: 2024-01-10)

• Primary citation: Leiros, H.S.,Edvardsen, K.S.W.,Bjerga, G.E.K.,Samuelsen, O.; Structural and Biochemical Characterization of Vim-26 Show that Leu224 Has Implications for the Substrate Specificity of Vim Metallo-Beta-Lactamases.; FEBS J., 282:1031-, 2015; PubMed: 25601024; DOI: 10.1111/FEBS.13200

Experimental method

X-RAY DIFFRACTION (1.555 Å)