4UVG
Discovery of pyrimidine isoxazoles InhA in complex with compound 15
Summary for 4UVG
Entry DOI | 10.2210/pdb4uvg/pdb |
Related | 4UVD 4UVE 4UVH 4UVI |
Descriptor | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | oxidoreductase, inha, acp enoyl reductase, fblg, pyrimidine isoxazole |
Biological source | MYCOBACTERIUM TUBERCULOSIS |
Total number of polymer chains | 1 |
Total formula weight | 29745.09 |
Authors | Read, J.A.,Gingell, H.,Madhavapeddi, P.,Ghorpade, S.,Cowan, S. (deposition date: 2014-08-05, release date: 2015-09-30, Last modification date: 2024-01-10) |
Primary citation | Madhavapeddi, P.,Kale, R.R.,Cowen, S.D.,Ghorpade, S.R.,Davies, G.,Bellale, E.V.,Kale, M.G.,Srivastava, A.,Spadola, L.,Kawatkar, A.,Raichurkar, A.V.,Tonge, M.,Nandishaiah, R.,Guptha, S.,Narayan, A.,Gingell, H.,Plant, D.,Landge, S.,Menasinakai, S.,Prabhakar, K.R.,Achar, V.,Ambady, A.,Sambandamurthy, V.K.,Ramachandran, V.,Panduga, V.,Reddy, J.,Kumar, C.N.N.,Kaur, P.,Shandil, R.,Iyer, P.S.,Narayanan, S.,Read, J.A. Hitting the Target in More Than One Way: Novel, Direct Inhibitors of Mycobacterium Tuberculosis Enoyl Acp Reductase To be Published, |
Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
Download full validation report