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4UV9

LSD1(KDM1A)-CoREST in complex with 1-Ethyl-Tranylcypromine

Summary for 4UV9
Entry DOI10.2210/pdb4uv9/pdb
Related4UV8 4UVA 4UVB 4UVC
DescriptorLYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS,10aS)-4a-[(1S,3E)-3-imino-1-phenylpentyl]-7,8-dimethyl-2,4-dioxo-1,3,4,4a,5,10a-hexahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate (3 entities in total)
Functional Keywordstranscription, covalent inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
More
Cellular locationNucleus: O60341 Q9UKL0
Total number of polymer chains2
Total formula weight148897.00
Authors
Primary citationVianello, P.,Botrugno, O.A.,Cappa, A.,Ciossani, G.,Dessanti, P.,Mai, A.,Mattevi, A.,Meroni, G.,Minucci, S.,Thaler, F.,Tortorici, M.,Trifiro, P.,Valente, S.,Villa, M.,Varasi, M.,Mercurio, C.
Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C:352-, 2014
Cited by
PubMed: 25173853
DOI: 10.1016/J.EJMECH.2014.08.068
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

217705

数据于2024-03-27公开中

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