4UQ3

Crystal structure of HLA-A0201 in complex with an azobenzene- containing peptide

4UQ3 の概要

• エントリーDOI: 10.2210/pdb4uq3/pdb
• 関連するPDBエントリー: 4UQ2
• 分子名称: HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, BETA-2-MICROGLOBULIN, AZOBENZENE-CONTAINING PEPTIDE, ... (5 entities in total)
• 機能のキーワード: immune system, azobenzene, hla-a, synthetic peptide
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 89517.69

構造登録者

Thong, S.Y.,Yap, J.W.,Lim, P.Y.,Verhelst, S.H.,Lescar, J.,Meijers, R.,Grotenbreg, G.M. (登録日: 2014-06-19, 公開日: 2014-09-17, 最終更新日: 2024-01-10)

主引用文献

Choo, J.A.,Thong, S.Y.,Yap, J.,van Esch, W.J.,Raida, M.,Meijers, R.,Lescar, J.,Verhelst, S.H.,Grotenbreg, G.M.
Bioorthogonal cleavage and exchange of major histocompatibility complex ligands by employing azobenzene-containing peptides.
Angew. Chem. Int. Ed. Engl., 53:13390-13394, 2014

PubMed Abstract: Bioorthogonal cleavable linkers are attractive building blocks for compounds that can be manipulated to study biological and cellular processes. Sodium dithionite sensitive azobenzene-containing (Abc) peptides were applied for the temporary stabilization of recombinant MHC complexes, which can then be employed to generate libraries of MHC tetramers after exchange with a novel epitope. This technology represents an important tool for high-throughput studies of disease-specific T cell responses.

PubMed: 25348595
DOI: 10.1002/anie.201406295

実験手法

X-RAY DIFFRACTION (2.1 Å)