4UN4
Crystal structure of Cas9 bound to PAM-containing DNA target with mismatches at positions 1-2
Summary for 4UN4
Entry DOI | 10.2210/pdb4un4/pdb |
Related | 4UN3 4UN5 |
Descriptor | SGRNA, CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, TARGET DNA STRAND PROXIMAL FRAGMENT, ... (7 entities in total) |
Functional Keywords | hydrolase-dna-rna complex, genome editing, rnp, protein-rna complex, hydrolase/dna/rna |
Biological source | STREPTOCOCCUS PYOGENES More |
Total number of polymer chains | 5 |
Total formula weight | 197779.31 |
Authors | Anders, C.,Niewoehner, O.,Duerst, A.,Jinek, M. (deposition date: 2014-05-25, release date: 2014-07-23, Last modification date: 2024-01-10) |
Primary citation | Anders, C.,Niewoehner, O.,Duerst, A.,Jinek, M. Structural Basis of Pam-Dependent Target DNA Recognition by the Cas9 Endonuclease Nature, 513:569-, 2014 Cited by PubMed: 25079318DOI: 10.1038/NATURE13579 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.371 Å) |
Structure validation
Download full validation report