4UMC

Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase - the importance of accommodating the active site water

4UMC の概要

• エントリーDOI: 10.2210/pdb4umc/pdb
• 関連するPDBエントリー: 4UMA 4UMB
• 分子名称: PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, MANGANESE (II) ION, PHOSPHATE ION, ... (5 entities in total)
• 機能のキーワード: transferase, dah7ps, dahps, aromatic amino acids, shikimate pathway, oxocarbenium ion, enzyme inhibitors, meningitis
• 由来する生物種: NEISSERIA MENINGITIDIS
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 156128.40

構造登録者

Heyes, L.C.,Reichau, S.,Cross, P.J.,Parker, E.J. (登録日: 2014-05-16, 公開日: 2014-10-08, 最終更新日: 2024-01-10)

• 主引用文献: Heyes, L.C.,Reichau, S.,Cross, P.J.,Jameson, G.B.,Parker, E.J.; Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase - the Importance of Accommodating the Active Site Water.; Bioorg.Chem., 57:242-, 2014; PubMed: 25245459; DOI: 10.1016/J.BIOORG.2014.08.003

実験手法

X-RAY DIFFRACTION (2.34 Å)