4UIY

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH N-(1,1-dioxo-1-thian-4-yl)- 5-methyl-4-oxo-7-3-(trifluoromethyl)phenyl-4H,5H-thieno-3,2-c- pyridine-2-carboximidamide

4UIY の概要

• エントリーDOI: 10.2210/pdb4uiy/pdb
• 関連するPDBエントリー: 4UIT 4UIU 4UIV 4UIW 4UIX 4UIZ
• 分子名称: BROMODOMAIN-CONTAINING PROTEIN 4, 1,2-ETHANEDIOL, N-[1,1-bis(oxidanylidene)thian-4-yl]-5-methyl-4-oxidanylidene-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide, ... (4 entities in total)
• 機能のキーワード: transcription, inhibitor, histone, epigenetic reader, bromodomain, brd4, bromodomain containing protein 4, antagonist
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15769.11

構造登録者

Chung, C.,Theodoulou, N.T.,Bamborough, P.,Humphreys, P.G. (登録日: 2015-04-03, 公開日: 2015-04-22, 最終更新日: 2024-05-08)

• 主引用文献: Theodoulou, N.H.,Bamborough, P.,Bannister, A.J.,Becher, I.,Bit, R.A.,Che, K.H.,Chung, C.,Dittmann, A.,Drewes, G.,Drewry, D.H.,Gordon, L.,Grandi, P.,Leveridge, M.,Lindon, M.,Michon, A.,Molnar, J.,Robson, S.C.,Tomkinson, N.C.O.,Kouzarides, T.,Prinjha, R.K.,Humphreys, P.G.; The Discovery of I-Brd9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.; J.Med.Chem., 59:1425-, 2016; PubMed: 25856009; DOI: 10.1021/ACS.JMEDCHEM.5B00256

実験手法