4UIT

BROMODOMAIN OF HUMAN BRD9 WITH 7-(3,4-dimethoxyphenyl)-2-(4- methanesulfonylpiperazine-1-carbonyl)-5-methyl-4H,5H-thieno-3,2-c- pyridin-4-one

4UIT の概要

• エントリーDOI: 10.2210/pdb4uit/pdb
• 関連するPDBエントリー: 4UIU 4UIV 4UIW 4UIX 4UIY 4UIZ
• 分子名称: BROMODOMAIN-CONTAINING PROTEIN 9, 7-(3,4-dimethoxyphenyl)-5-methyl-2-(4-methylsulfonylpiperazin-1-yl)carbonyl-thieno[3,2-c]pyridin-4-one (3 entities in total)
• 機能のキーワード: transcription, brd9, inhibitor, histone, epigenetic reader, bromodomain
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12719.78

構造登録者

Chung, C.,Theodoulou, N.T.,Bamborough, P.,Humphreys, P.G. (登録日: 2015-04-03, 公開日: 2015-04-22, 最終更新日: 2024-05-08)

• 主引用文献: Theodoulou, N.H.,Bamborough, P.,Bannister, A.J.,Becher, I.,Bit, R.A.,Che, K.H.,Chung, C.,Dittmann, A.,Drewes, G.,Drewry, D.H.,Gordon, L.,Grandi, P.,Leveridge, M.,Lindon, M.,Michon, A.,Molnar, J.,Robson, S.C.,Tomkinson, N.C.O.,Kouzarides, T.,Prinjha, R.K.,Humphreys, P.G.; The Discovery of I-Brd9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.; J.Med.Chem., 59:1425-, 2016; PubMed: 25856009; DOI: 10.1021/ACS.JMEDCHEM.5B00256

実験手法

X-RAY DIFFRACTION (1.3 Å)