4UHG

Crystal structure of human tankyrase 2 in complex with TA-21

Summary for 4UHG

Entry DOI	10.2210/pdb4uhg/pdb
Related	4UFU 4UFY 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8
Descriptor	TANKYRASE-2, ZINC ION, SULFATE ION, ... (6 entities in total)
Functional Keywords	transferase, protein-ligand complex, diphtheria toxin like fold, adp- ribosylation, transferase-transferase inhibitor complex
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: Q9H2K2
Total number of polymer chains	2
Total formula weight	55679.23
Authors	Haikarainen, T.,Lehtio, L. (deposition date: 2015-03-24, release date: 2016-04-13, Last modification date: 2016-05-25)
Primary citation	Nathubhai, A.,Haikarainen, T.,Hayward, P.C.,Munoz-Descalzo, S.,Thompson, A.S.,Lloyd, M.D.,Lehtio, L.,Threadgill, M.D. Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases. Eur.J.Med.Chem., 118:316-, 2016 Cited by PubMed: 27163581 DOI: 10.1016/J.EJMECH.2016.04.041 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation