4U6R

Crystal structure of human IRE1 cytoplasmic domains in complex with a sulfonamide inhibitor.

4U6R の概要

• エントリーDOI: 10.2210/pdb4u6r/pdb
• 関連するPDBエントリー: 4U79
• 分子名称: Serine/threonine-protein kinase/endoribonuclease IRE1, N-{4-[(3-{2-[(trans-4-aminocyclohexyl)amino]pyrimidin-4-yl}pyridin-2-yl)oxy]-3-methylnaphthalen-1-yl}-2-chlorobenzenesulfonamide, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: transferase, kinase, hydrolase, endoribonuclease, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Endoplasmic reticulum membrane ; Single-pass type I membrane protein : O75460
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53770.46

構造登録者

Mohr, C. (登録日: 2014-07-29, 公開日: 2014-10-08, 最終更新日: 2023-09-27)

• 主引用文献: Harrington, P.E.,Biswas, K.,Malwitz, D.,Tasker, A.S.,Mohr, C.,Andrews, K.L.,Dellamaggiore, K.,Kendall, R.,Beckmann, H.,Jaeckel, P.,Materna-Reichelt, S.,Allen, J.R.,Lipford, J.R.; Unfolded Protein Response in Cancer: IRE1 alpha Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability.; Acs Med.Chem.Lett., 6:68-72, 2015; PubMed: 25589933; DOI: 10.1021/ml500315b

実験手法

X-RAY DIFFRACTION (2.5 Å)