4U6M

Crystal structure of DNA/RNA duplex obtained in the presence of Spermine

Summary for 4U6M

• Entry DOI: 10.2210/pdb4u6m/pdb
• Related: 4U6K 4U6L
• Descriptor: RNA (5'-R(*GP*AP*AP*GP*AP*AP*GP*AP*G)-3'), DNA (5'-D(*(5CM)P*TP*CP*TP*TP*CP*TP*TP*(5CM))-3') (3 entities in total)
• Functional Keywords: dna/rna hybrid duplex, antisense, dna-rna complex, dna/rna
• Biological source: synthetic construct; More
• Total number of polymer chains: 2
• Total formula weight: 5642.68

Authors

Kondo, J.,Nomura, Y.,Kitahara, Y.,Obika, S.,Torigoe, H. (deposition date: 2014-07-29, release date: 2015-08-19, Last modification date: 2023-11-08)

Primary citation

Kondo, J.,Nomura, Y.,Kitahara, Y.,Obika, S.,Torigoe, H.
The crystal structure of a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer in complex with the target RNA.
Chem.Commun.(Camb.), 52:2354-2357, 2016

PubMed Abstract: It has been confirmed by our previous studies that a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer displays high affinity and selectivity to the target RNA strand, promising mRNA inhibitory activity and excellent nuclease resistance. Herein, we have obtained a crystal structure that provides insights into these excellent antisense properties.

PubMed: 26731288
DOI: 10.1039/c5cc08300a

Experimental method

X-RAY DIFFRACTION (1.9 Å)