4U5T

Crystal Structure of VBP Leucine Zipper with Bound Arylstibonic Acid

4U5T の概要

• エントリーDOI: 10.2210/pdb4u5t/pdb
• 分子名称: VBP leucine zipper, (2Z)-3-{3-[dihydroxy(oxido)-lambda~5~-stibanyl]phenyl}prop-2-enoic acid (3 entities in total)
• 機能のキーワード: leucine zipper, b-zip transcription factor, vitellogenin gene-binding protein (vbp), inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 9335.30

構造登録者

Stagno, J.R.,Ji, X. (登録日: 2014-07-25, 公開日: 2014-08-06, 最終更新日: 2023-08-30)

• 主引用文献: Zhao, J.,Stagno, J.R.,Varticovski, L.,Nimako, E.,Rishi, V.,McKinnon, K.,Akee, R.,Shoemaker, R.H.,Ji, X.,Vinson, C.; P6981, an arylstibonic acid, is a novel low nanomolar inhibitor of cAMP response element-binding protein binding to DNA.; Mol.Pharmacol., 82:814-823, 2012; PubMed: 22851716; DOI: 10.1124/mol.112.080820

実験手法

X-RAY DIFFRACTION (3.301 Å)