4U54
IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
Summary for 4U54
Entry DOI | 10.2210/pdb4u54/pdb |
Descriptor | Importin subunit alpha-1, N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine (3 entities in total) |
Functional Keywords | tpx2 inhibitor, transport protein |
Biological source | Mus musculus (Mouse) |
Cellular location | Cytoplasm : P52293 |
Total number of polymer chains | 1 |
Total formula weight | 46283.07 |
Authors | Stewart, M.,Valkov, E.,Holvey, R.S. (deposition date: 2014-07-24, release date: 2015-05-13, Last modification date: 2024-05-08) |
Primary citation | Holvey, R.S.,Valkov, E.,Neal, D.,Stewart, M.,Abell, C. Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10:1232-1239, 2015 Cited by PubMed: 25899172DOI: 10.1002/cmdc.201500014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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