4U4H

Crystal Structure of HSV-1 UL21 N-terminal Domain

4U4H の概要

• エントリーDOI: 10.2210/pdb4u4h/pdb
• 分子名称: Tegument protein UL21 (2 entities in total)
• 機能のキーワード: viral protein
• 由来する生物種: Human herpesvirus 1 (HHV-1)
• 細胞内の位置: Virion tegument: P10205
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23180.26

構造登録者

Metrick, C.M.,Heldwein, E.E. (登録日: 2014-07-23, 公開日: 2015-01-07, 最終更新日: 2023-12-27)

主引用文献

Metrick, C.M.,Chadha, P.,Heldwein, E.E.
The Unusual Fold of Herpes Simplex Virus 1 UL21, a Multifunctional Tegument Protein.
J.Virol., 89:2979-2984, 2015

PubMed Abstract: UL21 is a conserved protein in the tegument of alphaherpesviruses and has multiple important albeit poorly understood functions in viral replication and pathogenesis. To provide a roadmap for exploration of the multiple roles of UL21, we determined the crystal structure of its conserved N-terminal domain from herpes simplex virus 1 to 2.0-Å resolution, which revealed a novel sail-like protein fold. Evolutionarily conserved surface patches highlight residues of potential importance for future targeting by mutagenesis.

PubMed: 25540382
DOI: 10.1128/JVI.03516-14

実験手法

X-RAY DIFFRACTION (2.05 Å)