4U43
MAP4K4 in complex with inhibitor (compound 6)
Summary for 4U43
Entry DOI | 10.2210/pdb4u43/pdb |
Related | 4U3Y 4U3Z 4U40 4U41 4U42 4U44 4U45 |
Descriptor | Mitogen-activated protein kinase kinase kinase kinase 4, N-(pyridin-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (3 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : O95819 |
Total number of polymer chains | 2 |
Total formula weight | 75951.38 |
Authors | Harris, S.F.,Wu, P.,Coons, M. (deposition date: 2014-07-23, release date: 2014-09-03, Last modification date: 2023-12-27) |
Primary citation | Wang, L.,Stanley, M.,Boggs, J.W.,Crawford, T.D.,Bravo, B.J.,Giannetti, A.M.,Harris, S.F.,Magnuson, S.R.,Nonomiya, J.,Schmidt, S.,Wu, P.,Ye, W.,Gould, S.E.,Murray, L.J.,Ndubaku, C.O.,Chen, H. Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors. Bioorg.Med.Chem.Lett., 24:4546-4552, 2014 Cited by PubMed: 25139565DOI: 10.1016/j.bmcl.2014.07.071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.18 Å) |
Structure validation
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