4U32

Human mesotrypsin complexed with HAI-2 Kunitz domain 1

4U32 の概要

• エントリーDOI: 10.2210/pdb4u32/pdb
• 関連するPDBエントリー: 4U30
• 分子名称: Kunitz-type protease inhibitor 2, Trypsin-3, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: serine protease, protease inhibitor, protein-protein interaction, protein degradation, proteolysis, substrate specificity, enzyme kinetics, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Membrane ; Single-pass type I membrane protein : O43291; Secreted: P35030
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30822.99

構造登録者

Wang, R.,Soares, A.S.,Radisky, E.S. (登録日: 2014-07-18, 公開日: 2014-10-15, 最終更新日: 2023-12-27)

• 主引用文献: Pendlebury, D.,Wang, R.,Henin, R.D.,Hockla, A.,Soares, A.S.,Madden, B.J.,Kazanov, M.D.,Radisky, E.S.; Sequence and Conformational Specificity in Substrate Recognition: SEVERAL HUMAN KUNITZ PROTEASE INHIBITOR DOMAINS ARE SPECIFIC SUBSTRATES OF MESOTRYPSIN.; J.Biol.Chem., 289:32783-32797, 2014; PubMed: 25301953; DOI: 10.1074/jbc.M114.609560

実験手法

X-RAY DIFFRACTION (1.65 Å)