4U0I
Crystal structure of KIT in complex with ponatinib
4U0I の概要
エントリーDOI | 10.2210/pdb4u0i/pdb |
分子名称 | Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, PHOSPHATE ION, ... (4 entities in total) |
機能のキーワード | kit, receptor tyrosine kinase, inhibitor, ponatinib, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cytoplasm: P10721 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 36338.70 |
構造登録者 | |
主引用文献 | Garner, A.P.,Gozgit, J.M.,Anjum, R.,Vodala, S.,Schrock, A.,Zhou, T.,Serrano, C.,Eilers, G.,Zhu, M.,Ketzer, J.,Wardwell, S.,Ning, Y.,Song, Y.,Kohlmann, A.,Wang, F.,Clackson, T.,Heinrich, M.C.,Fletcher, J.A.,Bauer, S.,Rivera, V.M. Ponatinib Inhibits Polyclonal Drug-Resistant KIT Oncoproteins and Shows Therapeutic Potential in Heavily Pretreated Gastrointestinal Stromal Tumor (GIST) Patients. Clin.Cancer Res., 20:5745-5755, 2014 Cited by PubMed: 25239608DOI: 10.1158/1078-0432.CCR-14-1397 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
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