4U0F

Hexameric HIV-1 CA in Complex with BI-2

Summary for 4U0F

Entry DOI	10.2210/pdb4u0f/pdb
Related	4U0A 4U0B 4U0C 4U0D 4U0E
Descriptor	Capsid protein p24, 1,2-ETHANEDIOL, (4S)-4-(4-hydroxyphenyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one, ... (4 entities in total)
Functional Keywords	capsid, inhibitor, viral protein
Biological source	Human immunodeficiency virus type 1 group M subtype B (HIV-1)
Cellular location	Gag polyprotein: Host cell membrane; Lipid- anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion : P12493
Total number of polymer chains	1
Total formula weight	25814.64
Authors	Price, A.J.,Jacques, D.A.,James, L.C. (deposition date: 2014-07-11, release date: 2014-11-12, Last modification date: 2023-12-20)
Primary citation	Price, A.J.,Jacques, D.A.,McEwan, W.A.,Fletcher, A.J.,Essig, S.,Chin, J.W.,Halambage, U.D.,Aiken, C.,James, L.C. Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly. Plos Pathog., 10:e1004459-e1004459, 2014 Cited by PubMed: 25356722 DOI: 10.1371/journal.ppat.1004459 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.22 Å)

Structure validation