4TYT

Crystal Structure of BcII metallo-beta-lactamase in complex with ML302F

Summary for 4TYT

Entry DOI	10.2210/pdb4tyt/pdb
Descriptor	Beta-lactamase 2, ZINC ION, (2Z)-2-sulfanyl-3-(2,3,6-trichlorophenyl)prop-2-enoic acid, ... (6 entities in total)
Functional Keywords	antimicrobial resistance, metallo beta lactamase, inhibitor, hydrolase
Biological source	Bacillus cereus
Cellular location	Periplasm : P04190
Total number of polymer chains	1
Total formula weight	25598.07
Authors	Brem, J.,van Berkel, S.S.,McDonough, M.A.,Schofield, C.J. (deposition date: 2014-07-09, release date: 2014-11-26, Last modification date: 2023-12-20)
Primary citation	Brem, J.,van Berkel, S.S.,Aik, W.,Rydzik, A.M.,Avison, M.B.,Pettinati, I.,Umland, K.D.,Kawamura, A.,Spencer, J.,Claridge, T.D.,McDonough, M.A.,Schofield, C.J. Rhodanine hydrolysis leads to potent thioenolate mediated metallo-beta-lactamase inhibition. Nat.Chem., 6:1084-1090, 2014 Cited by PubMed: 25411887 DOI: 10.1038/nchem.2110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.799 Å)

Structure validation