4TY1

Crystal structure of human Pim-1 kinase in complex with an aminooxadiazole-indole inhibitor.

4TY1 の概要

• エントリーDOI: 10.2210/pdb4ty1/pdb
• 分子名称: Serine/threonine-protein kinase pim-1, N-tert-butyl-5-[3-(4-cyclopropylpyrimidin-2-yl)-1H-indol-5-yl]-1,3,4-oxadiazol-2-amine, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: transferase, serine/threonine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33530.95

構造登録者

Mohr, C. (登録日: 2014-07-07, 公開日: 2015-02-04, 最終更新日: 2023-12-27)

• 主引用文献: Wurz, R.P.,Pettus, L.H.,Jackson, C.,Wu, B.,Wang, H.L.,Herberich, B.,Cee, V.,Lanman, B.A.,Reed, A.B.,Chavez, F.,Nixey, T.,Laszlo, J.,Wang, P.,Nguyen, Y.,Sastri, C.,Guerrero, N.,Winston, J.,Lipford, J.R.,Lee, M.R.,Andrews, K.L.,Mohr, C.,Xu, Y.,Zhou, Y.,Reid, D.L.,Tasker, A.S.; The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors.; Bioorg.Med.Chem.Lett., 25:847-855, 2015; PubMed: 25599837; DOI: 10.1016/j.bmcl.2014.12.067

実験手法

X-RAY DIFFRACTION (2.7 Å)