4TXC

Crystal Structure of DAPK1 kinase domain in complex with a small molecule inhibitor

4TXC の概要

• エントリーDOI: 10.2210/pdb4txc/pdb
• 関連するPDBエントリー: 2YAK 4PF4
• 分子名称: Death-associated protein kinase 1, 4-(3-{3-[(R)-{[2-(dimethylamino)ethyl]amino}(hydroxy)methyl]phenyl}imidazo[1,2-b]pyridazin-6-yl)-2-methoxyphenol, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: protein-ligand complex, kinase, small-molecule, catalytic domain, protein kinase, protein binding, protein kinase inhibitors, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform 1: Cytoplasm. Isoform 2: Cytoplasm: P53355
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35571.33

構造登録者

Sorrell, F.J.,Krojer, T.,Wilbek, T.S.,Skovgaard, T.,Berthelsen, J.,Dixon-Clarke, S.,Chalk, R.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Stromgaard, K.,Knapp, S. (登録日: 2014-07-03, 公開日: 2014-07-23, 最終更新日: 2023-12-20)

• 主引用文献: Wilbek, T.S.,Skovgaard, T.,Sorrell, F.J.,Knapp, S.,Berthelsen, J.,Strmgaard, K.; Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1.; Chembiochem, 16:59-63, 2015; PubMed: 25382253; DOI: 10.1002/cbic.201402512

実験手法

X-RAY DIFFRACTION (1.951 Å)