4TWO
Human EphA3 Kinase domain in complex with compound 164
Summary for 4TWO
Entry DOI | 10.2210/pdb4two/pdb |
Descriptor | Ephrin type-A receptor 3, 5-{[3-carbamoyl-4-(3,4-dimethylphenyl)-5-methylthiophen-2-yl]amino}-5-oxopentanoic acid (3 entities in total) |
Functional Keywords | transferase/transferase inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P29320 |
Total number of polymer chains | 1 |
Total formula weight | 40832.63 |
Authors | Dong, J.,Caflisch, A. (deposition date: 2014-07-01, release date: 2015-05-13, Last modification date: 2023-12-20) |
Primary citation | Dong, J.,Zhao, H.,Zhou, T.,Spiliotopoulos, D.,Rajendran, C.,Li, X.D.,Huang, D.,Caflisch, A. Structural Analysis of the Binding of Type I, I1/2, and II Inhibitors to Eph Tyrosine Kinases. Acs Med.Chem.Lett., 6:79-83, 2015 Cited by PubMed: 25589935DOI: 10.1021/ml500355x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.047 Å) |
Structure validation
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