4TWD

X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with memantine

4TWD の概要

• エントリーDOI: 10.2210/pdb4twd/pdb
• 分子名称: Cys-loop ligand-gated ion channel, Memantine (2 entities in total)
• 機能のキーワード: elic, lgic, cys-loop, channel, memantine, pore blocker, transport protein
• 由来する生物種: Dickeya chrysanthemi (Pectobacterium chrysanthemi)
• 細胞内の位置: Cell inner membrane ; Multi- pass membrane protein : P0C7B7
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 354963.53

構造登録者

Ulens, C.,Spurny, R.,Thompson, A.J.,Alqazzaz, M.,Debaveye, S.,Lu, H.,Price, K.,Villalgordo, J.M.,Tresadern, G.,Lynch, J.W.,Lummis, S.C.R. (登録日: 2014-06-30, 公開日: 2014-09-24, 最終更新日: 2023-12-20)

• 主引用文献: Ulens, C.,Spurny, R.,Thompson, A.J.,Alqazzaz, M.,Debaveye, S.,Han, L.,Price, K.,Villalgordo, J.M.,Tresadern, G.,Lynch, J.W.,Lummis, S.C.; The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer's Disease Drug Memantine.; Structure, 22:1399-1407, 2014; PubMed: 25199693; DOI: 10.1016/j.str.2014.07.013

実験手法

X-RAY DIFFRACTION (3.2 Å)