4TW9

Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation

4TW9 の概要

• エントリーDOI: 10.2210/pdb4tw9/pdb
• 分子名称: Casein kinase I isoform delta, SULFATE ION, octyl beta-L-talopyranoside, ... (7 entities in total)
• 機能のキーワード: transferase, ck1delta, ck1epsilon, phosphorylation, small molecule inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71192.10

構造登録者

Richter, J.,Bischof, J.,Zaja, M.,Kohlhof, H.,Othersen, O.,Vitt, D.,Alscher, V.,Pospiech, I.,Garcia-Reyes, B.,Berg, S.,Leban, J.,Knippschild, U. (登録日: 2014-06-30, 公開日: 2014-07-30, 最終更新日: 2024-05-08)

• 主引用文献: Richter, J.,Bischof, J.,Zaja, M.,Kohlhof, H.,Othersen, O.,Vitt, D.,Alscher, V.,Pospiech, I.,Garcia-Reyes, B.,Berg, S.,Leban, J.,Knippschild, U.; Difluoro-dioxolo-benzoimidazol-benzamides As Potent Inhibitors of CK1 delta and epsilon with Nanomolar Inhibitory Activity on Cancer Cell Proliferation.; J.Med.Chem., 57:7933-7946, 2014; PubMed: 25191940; DOI: 10.1021/jm500600b

実験手法

X-RAY DIFFRACTION (2.4 Å)