4TSD

Crystal structure of Helicobacter pylori HP1029

4TSD の概要

• エントリーDOI: 10.2210/pdb4tsd/pdb
• 関連するPDBエントリー: 4TSZ
• 分子名称: HP1029, ZINC ION, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: unknown function, pfam family pf04074, zinc binding
• 由来する生物種: Helicobacter pylori 26695
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44946.23

構造登録者

Vallese, F.,Percudani, R.,Zanotti, G. (登録日: 2014-06-18, 公開日: 2015-06-10, 最終更新日: 2023-12-20)

主引用文献

Vallese, F.,Percudani, R.,Fischer, W.,Zanotti, G.
The crystal structure of Helicobacter pylori HP1029 highlights the functional diversity of the sialic acid-related DUF386 family.
Febs J., 282:3311-3322, 2015

PubMed Abstract: The proteins of the YhcH/YjgK/YiaL (DUF386) family have been implicated in the bacterial metabolism of host-derived sialic acids and biofilm formation, although their precise biochemical function remains enigmatic. We present here the crystal structure of protein HP1029 from Helicobacter pylori. The protein is a homodimer, in which each monomer comprises a molecular core formed by 12 antiparallel β-strands arranged in two β-sheets flanked by helices. The sandwich formed by the sheets assumes the shape of a funnel opened at one end, with a zinc ion present at the bottom of the funnel. The crystal structure unequivocally shows that HP1029 belongs to the DUF386 family. Although no bioinformatics evidence has been found for sialic acid catabolism in H. pylori, the genomic context of HP1029 in Helicobacter and related organisms suggests a possible role in the metabolism of bacterial surface saccharides, such as pseudaminic acid and its derivatives.

PubMed: 26096900
DOI: 10.1111/febs.13344

実験手法

X-RAY DIFFRACTION (1.53 Å)