4TQI
Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid in a dual binding mode
Summary for 4TQI
Entry DOI | 10.2210/pdb4tqi/pdb |
Related | 3GS0 4TQ8 4TQH 4TQP |
Descriptor | Transthyretin, (2S)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methylpropanoic acid, GLYCEROL, ... (4 entities in total) |
Functional Keywords | peg ttr crystallization, flourenone based amyloid antagonist and inhibitor, prealbumin, dual binding mode, hormone transporter, transport protein |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28301.52 |
Authors | Stura, E.A.,Ciccone, L.,Nencetti, S.,Rossello, A.,Orlandini, E. (deposition date: 2014-06-11, release date: 2015-06-24, Last modification date: 2023-09-27) |
Primary citation | Ciccone, L.,Nencetti, S.,Rossello, A.,Tepshi, L.,Stura, E.A.,Orlandini, E. X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem, :1-10, 2015 Cited by PubMed: 26235916PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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