4TQI

Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid in a dual binding mode

4TQI の概要

• エントリーDOI: 10.2210/pdb4tqi/pdb
• 関連するPDBエントリー: 3GS0 4TQ8 4TQH 4TQP
• 分子名称: Transthyretin, (2S)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methylpropanoic acid, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: peg ttr crystallization, flourenone based amyloid antagonist and inhibitor, prealbumin, dual binding mode, hormone transporter, transport protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted: P02766
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28301.52

構造登録者

Stura, E.A.,Ciccone, L.,Nencetti, S.,Rossello, A.,Orlandini, E. (登録日: 2014-06-11, 公開日: 2015-06-24, 最終更新日: 2023-09-27)

• 主引用文献: Ciccone, L.,Nencetti, S.,Rossello, A.,Tepshi, L.,Stura, E.A.,Orlandini, E.; X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors.; J Enzyme Inhib Med Chem, :1-10, 2015; PubMed: 26235916

実験手法

X-RAY DIFFRACTION (1.25 Å)