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4TNU

Human brain aspartoacylase mutant Y231C complex with intermediate analog (N-phosphonomethyl-L-aspartate)

Summary for 4TNU
Entry DOI10.2210/pdb4tnu/pdb
Related2o4h
DescriptorAspartoacylase, ZINC ION, N-[HYDROXY(METHYL)PHOSPHORYL]-L-ASPARTIC ACID, ... (4 entities in total)
Functional Keywordscanavan disease, zinc-dependent hydrolase, aspartoacylase family, aminoacylase-2, n-acetyl-l-aspartate, hydrolase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P45381
Total number of polymer chains2
Total formula weight72001.14
Authors
Wijayasinghe, Y.S.,Pavlovsky, A.G.,Viola, R.E. (deposition date: 2014-06-05, release date: 2014-07-30, Last modification date: 2023-09-27)
Primary citationWijayasinghe, Y.S.,Pavlovsky, A.G.,Viola, R.E.
Aspartoacylase catalytic deficiency as the cause of canavan disease: a structural perspective.
Biochemistry, 53:4970-4978, 2014
Cited by
PubMed: 25003821
DOI: 10.1021/bi500719k
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

217705

数据于2024-03-27公开中

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