4TMN
SLOW-AND FAST-BINDING INHIBITORS OF THERMOLYSIN DISPLAY DIFFERENT MODES OF BINDING. CRYSTALLOGRAPHIC ANALYSIS OF EXTENDED PHOSPHONAMIDATE TRANSITION-STATE ANALOGUES
Summary for 4TMN
Entry DOI | 10.2210/pdb4tmn/pdb |
Related | 5TMN |
Related PRD ID | PRD_000656 |
Descriptor | THERMOLYSIN, N-[(S)-[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl]-L-leucyl-L-alanine, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, metalloproteinase, hydrolase/hydrolase inhibitor |
Biological source | Bacillus thermoproteolyticus |
Cellular location | Secreted: P00800 |
Total number of polymer chains | 1 |
Total formula weight | 35107.55 |
Authors | Holden, H.M.,Tronrud, D.E.,Monzingo, A.F.,Weaver, L.H.,Matthews, B.W. (deposition date: 1987-06-29, release date: 1989-01-09, Last modification date: 2024-05-22) |
Primary citation | Holden, H.M.,Tronrud, D.E.,Monzingo, A.F.,Weaver, L.H.,Matthews, B.W. Slow- and fast-binding inhibitors of thermolysin display different modes of binding: crystallographic analysis of extended phosphonamidate transition-state analogues. Biochemistry, 26:8542-8553, 1987 Cited by PubMed: 3442675DOI: 10.1021/bi00400a008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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