4TLN

BINDING OF HYDROXAMIC ACID INHIBITORS TO CRYSTALLINE THERMOLYSIN SUGGESTS A PENTACOORDINATE ZINC INTERMEDIATE IN CATALYSIS

4TLN の概要

• エントリーDOI: 10.2210/pdb4tln/pdb
• 分子名称: THERMOLYSIN, CALCIUM ION, ZINC ION, ... (5 entities in total)
• 機能のキーワード: hydrolase (metalloproteinase)
• 由来する生物種: Bacillus thermoproteolyticus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34734.21

構造登録者

Matthews, B.W.,Holmes, M.A. (登録日: 1982-02-08, 公開日: 1982-05-26, 最終更新日: 2022-11-23)

• 主引用文献: Holmes, M.A.,Matthews, B.W.; Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis.; Biochemistry, 20:6912-6920, 1981; PubMed: 7317361; DOI: 10.1021/bi00527a026

実験手法

X-RAY DIFFRACTION (2.3 Å)