4S3A

IspG in complex with Intermediate I

4S3A の概要

• エントリーDOI: 10.2210/pdb4s3a/pdb
• 関連するPDBエントリー: 2Y0F 3NOY 4G9P 4S38 4S39 4S3B 4S3C 4S3D 4S3E 4S3F
• 分子名称: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, (3S)-1,3-dihydroxy-4-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}-2-methylbut-2-ylium, carbokation intermediate, IRON/SULFUR CLUSTER, ... (5 entities in total)
• 機能のキーワード: methylerythritol-phosphate pathway, terpene biosynthesis, iron-sulfur enzymes, reaction mechanisms, drug development, oxidoreductase
• 由来する生物種: Thermus thermophilus HB8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45092.95

構造登録者

Quitterer, F.,Frank, A.,Wang, K.,Rao, G.,O'Dowd, B.,Li, J.,Guerra, F.,Abdel-Azeim, S.,Bacher, A.,Eppinger, J.,Oldfield, E.,Groll, M. (登録日: 2015-01-26, 公開日: 2015-05-06, 最終更新日: 2023-12-06)

• 主引用文献: Quitterer, F.,Frank, A.,Wang, K.,Rao, G.,O'Dowd, B.,Li, J.,Guerra, F.,Abdel-Azeim, S.,Bacher, A.,Eppinger, J.,Oldfield, E.,Groll, M.; Atomic-Resolution Structures of Discrete Stages on the Reaction Coordinate of the [Fe4S4] Enzyme IspG (GcpE).; J.Mol.Biol., 427:2220-2228, 2015; PubMed: 25868383; DOI: 10.1016/j.jmb.2015.04.002

実験手法

X-RAY DIFFRACTION (1.6 Å)