4RY7
C-terminal mutant (D559E) of HCV/J4 RNA polymerase
4RY7 の概要
エントリーDOI | 10.2210/pdb4ry7/pdb |
関連するPDBエントリー | 1NB4 4RY4 4RY5 4RY6 |
分子名称 | HCV J4 RNA polymerase (NS5B) (2 entities in total) |
機能のキーワード | hepatitis c virus, replication, function analysis, viral rna polymerase, rdrp, rna rntp mg, nucleotide transfer, transferase |
由来する生物種 | Hepatitis C virus isolate HC-J4 (HCV) |
細胞内の位置 | Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : O92972 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 126941.55 |
構造登録者 | |
主引用文献 | Cherry, A.L.,Dennis, C.A.,Baron, A.,Eisele, L.E.,Thommes, P.A.,Jaeger, J. Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation. J.Virol., 89:2052-2063, 2015 Cited by PubMed: 25428878DOI: 10.1128/JVI.01106-14 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3 Å) |
構造検証レポート
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