4RX5

Bruton's tyrosine kinase (BTK) with pyridazinone compound 23

4RX5 の概要

• エントリーDOI: 10.2210/pdb4rx5/pdb
• 分子名称: Tyrosine-protein kinase BTK, SULFATE ION, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: protein kinase, phosphotransfer catalyst, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q06187
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32814.64

構造登録者

Eigenbrot, C.,Yu, C. (登録日: 2014-12-08, 公開日: 2015-12-02, 最終更新日: 2023-09-20)

• 主引用文献: Young, W.B.,Barbosa, J.,Blomgren, P.,Bremer, M.C.,Crawford, J.J.,Dambach, D.,Eigenbrot, C.,Gallion, S.,Johnson, A.R.,Kropf, J.E.,Lee, S.H.,Liu, L.,Lubach, J.W.,Macaluso, J.,Maciejewski, P.,Mitchell, S.A.,Ortwine, D.F.,Di Paolo, J.,Reif, K.,Scheerens, H.,Schmitt, A.,Wang, X.,Wong, H.,Xiong, J.M.,Xu, J.,Yu, C.,Zhao, Z.,Currie, K.S.; Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.; Bioorg.Med.Chem.Lett., 26:575-579, 2016; PubMed: 26675441; DOI: 10.1016/j.bmcl.2015.11.076

実験手法

X-RAY DIFFRACTION (1.356 Å)