Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (PSI community target)

Summary for 4RWA

Related4N6H 4EJ4 4RWD
Related PRD IDPRD_001256
DescriptorSoluble cytochrome b562,Delta-type opioid receptor, bifunctional peptide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (4 entities in total)
Functional Keywordshuman opioid receptor, bifunctional peptide, gpcr signaling, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, membrane, lipidic cubic phase, bril
Biological sourceEscherichia coli
Total number of polymer chains4
Total molecular weight92951.73
Primary citation
Fenalti, G.,Zatsepin, N.A.,Betti, C.,Giguere, P.,Han, G.W.,Ishchenko, A.,Liu, W.,Guillemyn, K.,Zhang, H.,James, D.,Wang, D.,Weierstall, U.,Spence, J.C.,Boutet, S.,Messerschmidt, M.,Williams, G.J.,Gati, C.,Yefanov, O.M.,White, T.A.,Oberthuer, D.,Metz, M.,Yoon, C.H.,Barty, A.,Chapman, H.N.,Basu, S.,Coe, J.,Conrad, C.E.,Fromme, R.,Fromme, P.,Tourwe, D.,Schiller, P.W.,Roth, B.L.,Ballet, S.,Katritch, V.,Stevens, R.C.,Cherezov, V.
Structural basis for bifunctional peptide recognition at human delta-opioid receptor.
Nat.Struct.Mol.Biol., 22:265-268, 2015
PubMed: 25686086 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb.2965
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27040.1%4.6%0.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report