4RVX

Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with non-peptidic inhibitor, GRL079

Summary for 4RVX

• Entry DOI: 10.2210/pdb4rvx/pdb
• Related: 4HLA 4NJT 4RVI 4RVJ 4RVV
• Descriptor: HIV-1 Protease, (4S)-4-amino-N-[(2S,3S)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]-3,4-dihydro-2H-chromene-6-carboxamide (3 entities in total)
• Functional Keywords: hydrolase, hydrolase-hydrolase inhibitor complex, hiv-1 protease-inhibitor complex, grl079, non-peptidic protease inhibitor, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 4
• Total formula weight: 44618.44

Authors

Yedidi, R.S.,Garimella, H.,Kaufman, J.D.,Das, D.,Wingfield, P.T.,Ghosh, A.K.,Mitsuya, H. (deposition date: 2014-11-28, release date: 2016-05-04, Last modification date: 2024-02-28)

• Primary citation: Yedidi, R.S.,Maeda, K.,Aoki, M.,Garimella, H.,Rao, K.V.,Akasapu, S.,Davis, D.A.,Kaufman, J.D.,Das, D.,Wingfield, P.T.,Amano, M.,Ghosh, A.K.,Mitsuya, H.; Enhanced antiviral activity by the P2-tris-tetrahydrofuran moiety of GRL-0519, a novel nonpeptidic HIV-1 protease inhibitor (PI), against multi-PI-resistant and highly darunavir-resistant strains of HIV-1.; To be Published,

Experimental method

X-RAY DIFFRACTION (1.955 Å)