4RVR

Crystal Structure of the bromodomain of human BAZ2B in complex WITH GSK2801

4RVR の概要

• エントリーDOI: 10.2210/pdb4rvr/pdb
• 関連するPDBエントリー: 4IR3 4IR4 4IR5 4IR6
• 分子名称: Bromodomain adjacent to zinc finger domain protein 2B, 1-{1-[2-(methylsulfonyl)phenyl]-7-propoxyindolizin-3-yl}ethanone, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: sgc, structural genomics consortium, transcription, acetylated lysine binding protein, kiaa1476, walp4, chemical probe
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q9UIF8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14362.51

構造登録者

Chaikuad, A.,Felletar, I.,Chung, C.W.,Drewry, D.,Chen, P.,Filippakopoulos, P.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2014-11-27, 公開日: 2014-12-10, 最終更新日: 2023-09-20)

• 主引用文献: Chen, P.,Chaikuad, A.,Bamborough, P.,Bantscheff, M.,Bountra, C.,Chung, C.W.,Fedorov, O.,Grandi, P.,Jung, D.,Lesniak, R.,Lindon, M.,Muller, S.,Philpott, M.,Prinjha, R.,Rogers, C.,Selenski, C.,Tallant, C.,Werner, T.,Willson, T.M.,Knapp, S.,Drewry, D.H.; Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.; J.Med.Chem., 59:1410-1424, 2016; PubMed: 25799074; DOI: 10.1021/acs.jmedchem.5b00209

実験手法

X-RAY DIFFRACTION (1.98 Å)