4RVJ

Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with amprenavir

Summary for 4RVJ

• Entry DOI: 10.2210/pdb4rvj/pdb
• Related: 4HLA 4NJS 4NJT 4NJU 4NJV 4RVI 4RVV 4RVX
• Descriptor: HIV-1 protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER (3 entities in total)
• Functional Keywords: hiv-1 protease-inhibitor complex, amprenavir, non-peptidic protease inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 4
• Total formula weight: 44466.25

Authors

Yedidi, R.S.,Garimella, H.,Kaufman, J.D.,Das, D.,Wingfield, P.T.,Mitsuya, H. (deposition date: 2014-11-26, release date: 2016-05-04, Last modification date: 2024-02-28)

• Primary citation: Yedidi, R.S.,Maeda, K.,Aoki, M.,Garimella, H.,Rao, K.V.,Akasapu, S.,Davis, D.A.,Kaufman, J.D.,Das, D.,Wingfield, P.T.,Amano, M.,Ghosh, A.K.,Mitsuya, H.; Enhanced antiviral activity by the P2-tris-tetrahydrofuran moiety of GRL-0519, a novel nonpeptidic HIV-1 protease inhibitor (PI), against multi-PI-resistant and highly darunavir-resistant strains of HIV-1; To be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)