4RUT

crystal structure of murine cyclooxygenase-2 with 13-methyl-arachidonic Acid

Summary for 4RUT

Entry DOI	10.2210/pdb4rut/pdb
Descriptor	Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	protein-ligand complex, prostaglandin-endoperoxide synthase, fatty acid analog, oxidoreductase, glycosylation, membrane
Biological source	Mus musculus (mouse)
Total number of polymer chains	4
Total formula weight	277135.12
Authors	Xu, S.,Kudalkar, S.N.,Banerjee, S.,Makriyannis, A.,Nikas, S.P.,Marnett, L.J. (deposition date: 2014-11-21, release date: 2015-02-11, Last modification date: 2023-09-20)
Primary citation	Kudalkar, S.N.,Nikas, S.P.,Kingsley, P.J.,Xu, S.,Galligan, J.J.,Rouzer, C.A.,Banerjee, S.,Ji, L.,Eno, M.R.,Makriyannis, A.,Marnett, L.J. 13-methylarachidonic Acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase. J.Biol.Chem., 290:7897-7909, 2015 Cited by PubMed: 25648895 DOI: 10.1074/jbc.M114.634014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.16 Å)

Structure validation