4RUR

Yeast 20S proteasome in complex with the alkaloid indolo-phakellin (4)

Summary for 4RUR

• Entry DOI: 10.2210/pdb4rur/pdb
• Related: 1RYP
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (17 entities in total)
• Functional Keywords: proteasome, alkaloid, reversible inhibition, drug discovery, halogen bonding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae S288c (Baker's yeast); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 28
• Total formula weight: 731989.93

Authors

Beck, P.,Lansdell, T.A.,Hewlett, N.M.,Tepe, J.J.,Groll, M. (deposition date: 2014-11-21, release date: 2014-12-10, Last modification date: 2023-09-20)

• Primary citation: Beck, P.,Lansdell, T.A.,Hewlett, N.M.,Tepe, J.J.,Groll, M.; Indolo-Phakellins as beta 5-Specific Noncovalent Proteasome Inhibitors.; Angew.Chem.Int.Ed.Engl., 54:2830-2833, 2015; PubMed: 25581903; DOI: 10.1002/anie.201410168

Experimental method

X-RAY DIFFRACTION (2.5 Å)