4RUD

Crystal structure of a three finger toxin

4RUD の概要

• エントリーDOI: 10.2210/pdb4rud/pdb
• 分子名称: Three-finger toxin 3b, ZINC ION (3 entities in total)
• 機能のキーワード: three finger toxin, snake venom toxin, toxin
• 由来する生物種: Micrurus fulvius (harlequin coralsnake)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 13217.79

構造登録者

Jobichen, C.,Sivaraman, J. (登録日: 2014-11-18, 公開日: 2016-05-18, 最終更新日: 2024-11-13)

主引用文献

Foo, C.S.,Jobichen, C.,Hassan-Puttaswamy, V.,Dekan, Z.,Tae, H.S.,Bertrand, D.,Adams, D.J.,Alewood, P.F.,Sivaraman, J.,Nirthanan, S.,Kini, R.M.
Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors.
Br.J.Pharmacol., 177:1822-1840, 2020

PubMed Abstract: Animal toxins have contributed significantly to our understanding of the neurobiology of receptors and ion channels. We studied the venom of the coral snake Micrurus fulvius fulvius and identified and characterized the structure and pharmacology of a new homodimeric neurotoxin, fulditoxin, that exhibited novel pharmacology at nicotinic ACh receptors (nAChRs).

PubMed: 31877243
DOI: 10.1111/bph.14954

実験手法

X-RAY DIFFRACTION (1.95 Å)