4RSP
X-ray structure of MERS-CoV nsp5 protease bound with a designed inhibitor
Summary for 4RSP
Entry DOI | 10.2210/pdb4rsp/pdb |
Related PRD ID | PRD_002174 |
Descriptor | Orf1a protein, Peptide inhibitor (3 entities in total) |
Functional Keywords | protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Middle East respiratory syndrome coronavirus More |
Cellular location | Host cytoplasm, host perinuclear region . Host membrane ; Multi-pass membrane protein : V9TU12 |
Total number of polymer chains | 2 |
Total formula weight | 33997.94 |
Authors | Tomar, S.,Mesecar, A.D. (deposition date: 2014-11-10, release date: 2015-06-17, Last modification date: 2023-12-06) |
Primary citation | Tomar, S.,Johnston, M.L.,St John, S.E.,Osswald, H.L.,Nyalapatla, P.R.,Paul, L.N.,Ghosh, A.K.,Denison, M.R.,Mesecar, A.D. Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS. J.Biol.Chem., 290:19403-19422, 2015 Cited by PubMed: 26055715DOI: 10.1074/jbc.M115.651463 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
Download full validation report